Friday, May 31, 2013

Sister Dearest

Identical twin brothers Isaac and Owen Wonner from Petersburg, OH, gather before taking part in in a look-alike contest during the final day of the 32nd annual Twins Days Festival in Twinsburg, Ohio August 5, 2007. There is a darker side to sibling love that even those with happy relationships with their siblings intuit

Photo by Jason Reed/Reuters

With the publication of Frank Bruni?s most emailed, much admired ode to sibling love, we seem to have found ourselves in another warm American moment that excludes or reproaches many people. When it?s great, there is nothing more transcendently close or comforting than one?s relationship with one?s siblings, but what Bruni didn?t get into is that it can also be a volatile and dangerous form of love.

There is a darker side to sibling love?especially for those very close in age?that even those with happy relationships with their siblings intuit. ?Of course you love your sister,? we tell our children, reassuringly. Though sometimes they don?t, or sometimes the rage or competition or desperation burns so brightly that they can?t precisely access that love. We like to tame the harrowing struggles between siblings with phrases like ?sibling rivalry? which reduce them to a harmless childhood phase one passes through, even though we know from casual observation this is not true. (There are, in fact, a spate of new books out recently, or coming out, that, each in their own way, explore the darker side of sibling love: Lucinda Rosenfeld?s The Pretty One, Curtis Sittenfeld?s Sisterland, and Lauren Sandler?s forthcoming celebration of only children, One and Only.)

Like Bruni, I am lucky enough to come from a big brood. I am very close to two of my sisters, and don?t know what I would do without them.

But when I had a baby on my own, in challenging circumstances, one of my other sisters did not want to meet him. Our relationship had been extremely strained since before I was pregnant, but I thought she might want to see her nephew, in the ritual way one sees a new baby. She lived, at the time, in the duplex upstairs from us, but she did not come down to hold him. She did not send a onesie with airplanes on it or a bear. She and her husband and daughter did not come to the party I had in my garden to welcome him to the world. She, in fact, did not meet or look at him for five months. That?s how much she hated or resented me.

In the last weeks of my pregnancy, several friends offered to drive me to the hospital or watch my daughter if there was an emergency because they knew that I was alone, and my sister, who lived upstairs and had a car, was not on friendly enough terms to drive me to the hospital. Very late at night, I considered the possibility that those people who you would call in the middle of the night to drive you to the hospital or to watch your other child if something went wrong are in fact your family. ?

When we got home from the hospital my 6-year-old daughter would ask every day why her aunt had not come to meet our baby. My first instinct was to lie, to protect the idea of family love winning out, to smooth over, to make things normal for her, but there was no way to do this for five months. In the end, I think she learned that your siblings, or at least sisters, may or may not show up for you when you need them.

Of course I was struck in particular by Frank Bruni?s line about his siblings: ?For each of us, a new home, a new relationship or a newborn was never quite real until the rest of us had been ushered in to the front row.? But of course, even if your sister does not show up the newborn will still crush up his face and cry when he is hungry; he will still find a way to be real. And even though we tend in America to get pretty oppressed by traditional ideas or fantasies about these things, you can still make or find a family for him.

Rather than delve too deeply into my own depressing relationship with my sister, which went radically downhill in terms of sisterly love and support in the two years after the baby was born, I?ll trot out as Exhibit A Virginia Woolf and her sister, the painter Vanessa Bell. They were astonishingly, sort of beautifully close, and adored each other. In fact, when Vanessa got engaged Virginia wrote this in a whimsical letter: ?We the undersigned three Apes and a Wombat wish to make known to you our great grief and joy at the news that you intend to marry.We have wooed you and sung many songs of winter and summer and autumn in the hope that thus enchanted you would condescend one day to marry us. But as we no longer expect this honor we entreat that you keep us still for your lovers ??

Later, when Vanessa had a baby, both Virginia and Vanessa?s husband, Clive felt like they weren?t getting enough of Vanessa?s attention. In the difficult period that followed Virginia began a sort of affair, with Clive that was incredibly painful for Vanessa.

The two sisters salvaged their relationship, and were closely attached to the end, though the episode remained, huge and looming, beneath the surface. (One way they managed, which is arguably a good way to manage siblings, was that they were English, so they just didn?t talk much about it.) The thing one learns from these two high strung women is that the intensity or intimacy or possessiveness of the sibling relationship is amazing, well, until it?s not. The familiarity, the closeness, the seduction of a shared childhood carries within it a lot of dangerous things; the wonderful elements of siblings co-exist with the very awful ones, they are entwined, inseparable. And whether it works like Frank Bruni?s clan, or doesn?t, there is no point in an overly rosy or hallmarkish view.

Now my sister is living happily ever after with her corporate lawyer husband in a world that is fortunately very different from my own; we are freed from the thwarted expectations of shared history. You can fight forever over a game that was played decades earlier, or a half remembered argument in a bedroom with elephant wallpaper in a house that was sold long ago, or you can walk away. ?

Part of the problem may be that the thing you suspect as a child?that there is not enough love to go around?is true. Attention is finite. The scramble is forever. The secretly suspected truth that you are not equally admired or adored or attractive, that there will be insoluble inequities, that one will have a more interesting career, and one will be happier in love, and one will have better adventures, and one will be more creative, and one will be more charming, and one will have more shoes is all true. The myth parents foist, with good intentions, on children?that the resources and embrace of the world will be equal?will not be borne out by life. You knew it when you were 4. The yellow lollipop is not the same as the red one.

Source: http://www.slate.com/articles/double_x/roiphe/2013/05/frank_bruni_s_new_york_times_column_on_sibling_love_misses_the_dark_side.html

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Equity crowdfunding by unaccredited investors is legal in exactly ...

Almost a year after President Obama signed the JOBS Act into law, crowdfunding for equity is still not legal ? at least for the 99 percent of people that are not accredited investors. But there is at least one place in North America where crowdfunding for equity has been legal for a decade.

That?s British Columbia, just north of Washington State in Canada, where Vancouver ranks as the ninth ?top startup ecosystem globally.

?BC has had legalized crowdfunding for a decade,? super-angel Mike Volker said last night at the Vancouver Enterprise Forum event on crowdfunding. ?It?s the only place in North America, and there are?no restrictions, no limits.?

Volker has been an angel for 30 years, and currently runs two mutual-fund like investment pools that invest in startups. One is set up ?normally? for accredited investors, and one uses a unique instrument to British Columbia: an ?offering memorandum,? which allows?an startup to sell its securities to anyone, regardless of their relationship, wealth, or minimum value of securities being purchased.

Crowdfunding for startups is now legal in the U.S., and you can actually market your equity online now, but only to accredited investors. The Crowdfund Act opened some doors, but only that one percent of the population can participate. That?s an unfortunately small crowd.

Mike Volker on a panel at VEF (second from left)

Source: John Koetsier

Mike Volker on a panel at VEF (second from left)

And even when it works, crowdfunding for equity in the U.S. has onerous reporting requirements?which could cost up to $10,000 or more for a raise of only $100,000.

The only requirement in British Columbia? Audited financial statements. Approximate cost: perhaps $3000.

That?s something that U.S. crowdfunding sites like Fundable would love to be able to offer, but cannot legally today. And it doesn?t look likely, given the massive amount of SEC regulation that currently encumbers the JOBS act and the Crowdfund Act. In fact, some crowdfunding investors say that the way the SEC has implemented the new law has actually made investing harder, not easier.

?In their attempts to make this happen the SEC has made it?very complicated for portals and brokers,? Volker said. ?You need a broker,?so he needs a commission, and then the broker has tremendous responsibilities such as validating criminal record checks. It?s basically like a mini-IPO, and?I predict it?s not going to do very well.?

But be careful what you wish for, American investors.

In spite of its availability the offering memorandum has not resulted in a flood of funding, crowd or otherwise. In fact, Volker says, it?s pretty much gone unnoticed:

?Everyone in BC can do it, and most BCers don?t know it.?

Perhaps that?s because it was too early, too bleeding edge. And perhaps now in the age of Kickstarter and Indiegogo it has a much better chance. There are certainly interesting places to use it, and entrepreneurs who would find it useful.

?You can use the offering memorandum if you have investors lined up who don?t meet the angel investor qualifications,? Volker says. ?It?s?also useful if you?ve raised $400, 000 via angels and now you want to bring on micro-angels or cherubs and add a little more.?

photo credit: marfis75 via photopin cc

Source: http://venturebeat.com/2013/05/29/crowdfunding-for-equity-by-unaccredited-investors-is-legal-in-exactly-one-place-in-north-america/

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Thursday, May 30, 2013

New gene delivery method: Magnetic nanoparticles

May 30, 2013 ? Stent angioplasty saves lives, but there often are side effects and complications related to the procedure, such as arterial restenosis and thrombosis. In the June 2013 issue of The FASEB Journal, however, scientists report that they have discovered a new nanoparticle gene delivery method that may overcome current limitations of gene therapy vectors and prevent complications associated with the stenting procedure. Specifically, this strategy uses stents as a platform for magnetically targeted gene delivery, where genes are moved to cells at arterial injury locations without causing unwanted side effects to other organs.

Additionally, magnetic nanoparticles developed and characterized in the study also protect genes and help them reach their target in active form, which also is one of the key challenges in any gene therapy.

"This study can help address a number of barriers to translation of experimental gene therapeutic approaches to clinical practice," said Michael Chorny, Ph.D., a researcher involved in the work from the Division of Cardiology at the Abramson Pediatric Research Center at The Children's Hospital of Philadelphia in Pennsylvania. "Bringing gene therapy closer to clinical use is a step toward developing safer and more effective ways for treating cardiovascular disease."

To make this technique possible, Chorny and colleagues used in vitro vascular cells to demonstrate the ability to effectively deliver genes using biocompatible nanoparticles and magnetic force without causing adverse effects. Although effective gene transfer in these cells has been difficult to achieve historically, this study demonstrated that magnetically guided "gene-impregnated" nanoparticles delivered their cargo effectively, especially compared to conventional gene delivery vectors. Next, researchers explored magnetically targeted gene delivery by applying these nanoparticles to stented arteries in rats. The nanoparticle-mediated expression of stent-targeted genes was shown to be greatly enhanced in treated animals when compared to control groups treated with nanoparticles without using the magnetic conditions, or with an equivalent dose of a conventional gene delivery vector. Genes delivered using the magnetically targeted nanoparticles were also expressed at considerably higher levels in the stented arteries compared to other organs and tissues.

"This approach is novel and exciting, and goes to show that investments in basic science across disciplines pay off in time," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "When the first nanoparticles were developed and when the first correctable human disease gene was identified, no one could have ever known that these two advances would come together in a way that might one-day save lives."

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Story Source:

The above story is reprinted from materials provided by Federation of American Societies for Experimental Biology, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. M. Chorny, I. Fishbein, J. E. Tengood, R. F. Adamo, I. S. Alferiev, R. J. Levy. Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors. The FASEB Journal, 2013; 27 (6): 2198 DOI: 10.1096/fj.12-224659

Note: If no author is given, the source is cited instead.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/N8FLn0vtLAs/130530111153.htm

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Five Amazon pilots get the green light

Five Amazon pilots get the green light

Well, it seems that you, the web video watching public, has spoken. Amazon announced today that it has whittled its robust list of pilots down to five titles, thanks to viewers like you. Winners will be turned into series available to users of Amazon Prime Instant Video and Lovefilm later this year and in early 2014. That list includes the John Goodman political comedy Alpha House, the startup-centric Betas and the kids series Annebots, Creative Galaxy and Tumbleleaf. For the full press release and quotes from the folks behind the series being various states of "thrilled," click on through the break.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/kLFqR67ZOQg/

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Wednesday, May 29, 2013

Senator Boxer calls for probe on California nuclear plant

Sen. Barbara Boxer (D) of California charges that Southern California Edison intentionally misled regulators in order to avoid an extensive safety review of upgrades to its San Onofre nuclear plant. Senator Boxer has called on the Justice Department to investigate.

By David J. Unger,?Correspondent / May 28, 2013

Surfers walk along a beach near the San Onofre nuclear power plant in San Onofre, Calif. The plant closed in January 2012 after a radioactive leak led to the discovery of wear in tubing that carries radioactive water.

Grant Hindsley/AP/File

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The operator of a California nuclear plant is under fire from a US senator for allegedly misrepresenting the nature of an equipment upgrade that resulted in a small radioactive leak at the plant last year.

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Why It Matters

Energy: About 20 percent of electricity generation in the US comes from nuclear power.

Environment: Nuclear power produces zero carbon emissions but runs the risk of radioactive leaks.

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It's another blow to Southern California Edison (SCE), which has worked to reopen the closed San Onofre Nuclear Generating Station for over a year. The fallout has cost the company more than?$553 million and drawn attacks from environmentalists who say the plant is inherently unsafe.

On Tuesday,?Sen. Barbara Boxer (D) of California released a private company letter she says is evidence of the company?intentionally misleading regulators in order to avoid an extensive safety review of upgrades to San Onofre. She has called on the Justice Department to investigate.

"Given this new information, it is clear to me that in order for this nuclear plant to even be considered for a restart in the future all investigations must be completed and a full license amendment and public hearing process must be required," Ms. Boxer said in a statement Tuesday. "This is simply a common sense approach."?

The Magazine switches owners from Marco Arment to Glenn Fleishman, gets all-star support team

The Magazine switches owners from Marco Arment to Glenn Fleishman, gets all-star support team

Marco Arment's The Magazine is now Glenn Fleishman's. That's right, the former executive editor is the new owner, and he's assembled an all-star team to help him continue The Magazine's mission going forward. From the press release:

"Marco gave me an incredible amount of freedom in editing The Magazine, and I'm happy to add the role of publisher as it develops further," Fleishman said. Writer and editor Brittany Shoot has been retained as The Magazine's managing editor.

Aperiodical has already contracted several firms to update and extend the Web site's and app's design and programming. Design and interaction company Pacific Helm worked with Arment to design the app, worked on previous iterations of the Web site, and created each of the issue covers. They will continue in those roles.

Guy English and Chris Parrish of Aged & Distilled will handle iOS app development. They recently released the Napkin app for Mac OS X. Jessica Simmons of Simmons Ardell, formerly of sister design firms Milton Glaser Inc and WBMG, has signed on to design an upcoming print collection drawn from both the first 100 articles appearing in The Magazine and newly commissioned work. Dean Putney, one of the main developers behind top blog BoingBoing, will manage improvements on the Web site.

Fleishman plans to add a regular podcast of interviews with authors and their subjects. The podcast will include sponsorships handled by Lex Friedman, of the podcast-advertising network Podlexing. A revision of the Web site will launch June 1, followed in the near future by an update to the iOS app with user-requested features.

That's a hell of a lot of amazing talent, and the caliber of writers has been just as phenomenal since launch. The Magazine is already great, and I can't wait to see how they make it even better.

Arment also sold a majority interest in Instapaper to Betaworks a few weeks ago, and while no longer with the company, he was also the original developer behind Tumblr, which just sold to Yahoo! Since Arment isn't someone to suffer boredom easily or for long, it'll be interesting to see what he creates next. For now, you can find his blog at Marco.org and his podcast at ATP.fm.

In the meantime, congrats to all involved!

Source: Press release

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/iMNAMUdjFT4/story01.htm

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Ancient Cave Art Unearthed in Northeastern Mexico

In northeastern Mexico, archaeologists found ancient paintings on the walls of caves before Spanish rule. (Photo : Reuters)

In northeastern Mexico, archaeologists found ancient paintings on the walls of caves before Spanish rule. Livescience.com reported that the art shows evidence of native cultures that lived in the area around Sierra de San Carlos which is a mountain range in Tamaulipas.

There wer almost 5,000 paintings found in the region. "Created with red, yellow, black and white pigments, the images show animals from deer to lizards to centipedes, as well as people. Depictions of tents, hunting, fishing and possibly?astronomical charts?also offer a glimpse into the life of this mysterious culture," reported Livescience.com.

Archaologist Gustvao Ramirez from the Mexican National Institute of Anthropology and History said in a press release that the discovery shows the presence of pre-Hispanic groups, "where before it was said that there was nothing, when in fact it was inhabited by?one or more cultures."

The Agence France Presse reported that researchers will try to find out the age of the artwork by using chemical and radiocarbon analyses. The colors they used were made using organic dyes and minerals said the INAH press release.

"We have not found any ancient objects linked to the context, and because the paintings are on ravine walls and in the rainy season the sediments are washed away, all we have is gravel," added Ramirez, reported LiveScience.com.

The History Channel said on its website that there may have been nomadic tribes as far back as 6000 BC in Tamaulipas. Then between 1445 and 1466 Aztec armies conquered a lot of the region.

"These tribes of primitive men, women and children resembled wandering gypsies except for the fact that they remained fixed in a natural niche within the boundaries of which they had freedom of movement. They escaped the greedy and authoritarian clutches of the gold-diggers who had arrived from across?the?Atlantic,
?reported I4UNews.com.

The findings were presented ?recently during the Second Conference of Archaeological History in Mexico City.

Source: http://www.travelerstoday.com/articles/6414/20130528/ancient-cave-art-unearthed-northeastern-mexico.htm

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Florida overcomes injury, illness woes to qualify for NCAA Championships



Florida junior T.J. Vogel, who sustained a sports hernia before the spring season began, helped the Gators qualify for their 13th straight trip to the NCAA Championships.

Brad McClenny / Staff photographer

Published: Tuesday, May 28, 2013 at 6:01 a.m.
Last Modified: Monday, May 27, 2013 at 11:34 p.m.

In his 26-year coaching career at Florida, Buddy Alexander's golf teams have somehow managed to avoid the potential season-altering setbacks that no coach can control.

Injuries, illness and accidents.

?I've been really lucky through the years with injuries,? said Alexander, whose team opens play today in the NCAA Championships at the Capital City Club-Crabapple Course in Woodstock, Ga. ?In 1990, Dudley Hart broke a rib and couldn't play in the SEC Tournament and we got beat in a playoff. Other than that, literally, I've had nothing go wrong from an injury and illness standpoint.?

Alexander's luck ran out this season. The injury/illness/accident bug finally caught up with the Gators.

It started with Eric Banks undergoing open-heart surgery that sidelined him for six months between his freshman and sophomore seasons. Then No. 2 golfer T.J. Vogel sustained a sports hernia injury just before the start of the spring season. No. 1 golfer Tyler McCumber opened the spring season with walking pneumonia. Vogel and others came down with the flu early in the season.

?It's been an interesting season from that standpoint,? Alexander said.

It's a season that has been impacted by illness and injury. The Gators pretty much stumbled through the spring, winning zero tournaments with a best finish of fourth place.

Now, the latest: J.D. Tomlinson's toe. The sophomore from Gainesville has stitches in his right big toe after cutting it on some tile by the family pool. He is expected to be fine for the NCAA Championships.

Here's the good news for the Gators: Other than Tomlinson's toe, the Gators are feeling better and playing better than they have all spring heading into the tournament. UF's luck hasn't been good, but its timing could not be better.

?We've got a couple guys (McCumber and Vogel) playing well at the right time,? Alexander said. ?My team is doing OK.?

The Gators did not appear OK a month ago. They seemed in full fade mode after finishing a dismal 10th in the SEC Tournament.

But two weeks after that, in the NCAA Regional in Baton Rouge, the Gators regained their fall form (where they won one tournament and had two seconds) and finished second, easily qualifying for UF's 13th consecutive NCAA Championships.

After their strong performance in the regional, the Gators are starting to feel like they just might have a national championship run in them.

?How we played at regionals is who we are,? Vogel said. ?We're that good. We can play with (No. 2) Alabama. We've almost beaten them a few times this year. We know we can play with them.

?We know if we play our game, we can play with the best. We want to make it to match play. We feel confident. Once you get to match play (as one of the top eight teams following 54 holes of stroke play), anything can happen.?

Vogel and McCumber seem to be coming on at the right time. Both finished the regional at 1-under par. Alexander said the play of the two seniors will be critical to UF's chances this week.

?They will be hugely important,? Alexander said. ?When you have two really good players like we do, those guys are going to have to play well.?

McCumber seems like a sure thing.

?You can't say enough about Tyler McCumber,? Alexander said. ?This guy has been amazing. In his last five postseason events, he's got four top-three finishes. Think about that.

?I don't think there's been anybody at the University of Florida, or maybe anywhere, that's got a stretch of play quite that good.?

McCumber said the Gators are now playing the way everyone thought they would coming out of a successful fall season.

?We were trying to build momentum (this spring) and we finally saw it come together at the regional,? he said. ?Everyone's hard work paid off. Everybody is pretty positive. That's how we're capable of playing, if not better. It was nice to finally see it.

?We had some injuries and incidents that set us back a little bit (in the spring). But we're moving in the right direction at the right time.?

Alexander said the spring injuries and struggles will be forgotten if the Gators play well this week.

?Postseason is what it's all about,? Alexander said. ?We're going to be measured forever on what we do this week.

?Nobody remembers what happened at the Gator Invitational in 2004. But I can tell you what we finished in the NCAAs that year. This week is what it's all about.?

Source: http://www.gainesville.com/article/20130528/articles/130529648

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Tuesday, May 28, 2013

EU foreign ministers seek solution on Syria arms

BRUSSELS (AP) ? The European Union nations remain divided on Monday whether to ease sanctions against Syria to allow for weapons shipments to rebels fighting the regime of Syria's President Bashar Assad.

Britain is the most outspoken proponent of relaxing the arms embargo but faces opposition from some members that feel more weapons would only increase the killings, Dutch Minister Frans Timmermans said,

"As we begin our meeting there are still different views," Timmermans said, heading into of the meeting of the bloc's foreign ministers.

Assad has been using extensive firepower against lightly armed rebel factions. More than 70,000 people have died since the uprising against Assad's regime erupted in March 2011. Meanwhile, both sides have agreed in principle to enter direct talks in Geneva next month.

Several nations say that arming the opposition would create a level playing field that would force Assad into a negotiated settlement.

"It is important to show we are prepared to amend our arms embargo so that the Assad regime gets a clear signal that it has to negotiate seriously," said British Foreign Secretary William Hague.

The date, agenda and list of participants for the conference remain unclear, and wide gaps persist about its objectives.

Austria was among the holdouts to keep the EU from providing weapons, arguing it would only acerbate an already horrific situation.

"We are not involved in conflicts by delivering arms to one side and we should stay as a peace community by not being involved in such a conflict," Austrian Foreign Minister Michael Spindelegger said.

"To turn and reverse our line would not help in the conflict," he said. Any decision would require unanimity among the 27 member states.

There are also fears that delivering weapons to the opposition would open the way for extremist groups and terrorists to get hold of weapons that could then be targeted against the EU.

Hague, however, said that standing still was no option and that the moderate opposition needed to be boosted.

"Most of the world denies them the means to defend themselves, so that is creating extremism radicalizing people. We are reaching the limits of how long we can go on with that situation."

Source: http://news.yahoo.com/eu-foreign-ministers-seek-solution-syria-arms-080418834.html

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Monday, May 27, 2013

Nurse admits murdering 11, after lying about rescue attempts

A registered nurse admits murdering 11 inmates by burning down a nursing home. Earlier, he told TV reporters that he had heroically tried to rescue trapped victims of the fire.

By Associated Press / May 27, 2013

A?nurse?has pleaded guilty to murdering 11 elderly people by setting?fire?to the Sydney nursing?home where he worked.

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Roger Dean also pleaded guilty to causing grievous bodily harm to another eight?nursing?home residents injured by the blaze in 2011.

The 37-year-old registered?nurse?was on duty when he set the?fire?and later appeared on television describing his efforts to rescue trapped people at the?nursing?home in the suburb of Quakers Hill.

He made his pleas in New South Wales state Supreme Court on Monday. His sentencing hearing starts on Thursday. He potentially faces life imprisonment.

Police had questioned him at the home hours before the blaze over theft allegations. He has already pleaded guilty to stealing prescription drugs from the home.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/ichYFjjHWTQ/Nurse-admits-murdering-11-after-lying-about-rescue-attempts

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7 Ways To Sleep Better Tonight

7 Ways To Sleep Better Tonight

SparkPeople:

I'm a married woman, but there's a guy I've been chasing after for months: the Sandman. I want him desperately some nights -- and then other evenings I push him away. It's completely my fault that he's turned his back on me in bed. Our always-too-short encounters are rarely satisfying because I'm constantly thinking about an errand I forgot to run or a form I need to fill out for my son's school. (Even Overstock.com and Candy Crush Saga come between us.) Yes, in terms of sleep time, I could -- and should -- do better.

Read the whole story: SparkPeople

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I'm a married woman, but there's a guy I've been chasing after for months: the Sandman. I want him desperately some nights -- and then other evenings I push him away. It's completely my fault that he'...

I'm a married woman, but there's a guy I've been chasing after for months: the Sandman. I want him desperately some nights -- and then other evenings I push him away. It's completely my fault that he'...

Filed by Sarah Klein ?|?

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    1. HuffPost
    2. Healthy Living
  • ?

    Source: http://www.huffingtonpost.com/2013/05/26/sleep-better-tonight_n_3332651.html

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    Angelina Jolie's aunt dies of breast cancer

    (Reuters) - Angelina Jolie's aunt died of breast cancer on Sunday, a hospital spokesman in California said, nearly two weeks after the actress wrote about electing to have a double mastectomy after learning she had inherited a high risk of breast cancer.

    Debbie Martin, the younger sister of Jolie's mother, died at age 61 at Palomar Medical Center in Escondido, near San Diego.

    Her husband, Ron Martin, told Britain's Sky News that his wife had the same defective BRCA1 gene as Jolie.

    Jolie's mother, Marcheline Bertrand, died of breast cancer in 2007 at age 56.

    On May 14, Jolie, the Oscar-winning film star, revealed she had a double mastectomy in an article in the New York Times, saying she hoped her story would inspire other women fighting the life-threatening disease.

    Jolie, 37, is raising a family with fellow actor and fiance Brad Pitt. She wrote that she went through with the operation in part to reassure her six children that she would not die young from cancer, as her own mother did.

    "We often speak of 'Mommy's mommy,' and I find myself trying to explain the illness that took her away from us. They have asked if the same could happen to me," wrote Jolie.

    "I have always told them not to worry, but the truth is I carry a 'faulty' gene."

    The actress, who won an Oscar as best supporting actress for her 1999 role in the film "Girl, Interrupted," said she opted for the surgery after her doctors had estimated she had an 87 percent risk of breast cancer and 50 percent risk of ovarian cancer, due to an inherited genetic mutation.

    (Reporting by Jane Sutton and Daniel Trotta; Editing by Peter Cooney and Bill Trott)

    Source: http://news.yahoo.com/angelina-jolies-aunt-dies-breast-cancer-041525062.html

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    First drug to significantly improve heart failure mortality in over a decade

    May 25, 2013 ? Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality in over a decade and should be added to standard treatment, according to lead author Professor Svend Aage Mortensen (Copenhagen, Denmark).

    Heart Failure 2013 is being held from 25-28 May in Lisbon, Portugal. It is the main annual meeting of the Heart Failure Association of the European Society of Cardiology (1).

    Coenzyme Q10 (CoQ10) occurs naturally in the body and is essential to survival. CoQ10 works as an electron carrier in the mitochondria, the powerhouse of the cells, to produce energy and is also a powerful antioxidant. It is the only antioxidant that humans synthesise in the body.

    CoQ10 levels are decreased in the heart muscle of patients with heart failure, with the deficiency becoming more pronounced as heart failure severity worsens. Statins are used to treat many patients with heart failure because they block the synthesis of cholesterol, but these drugs also block the synthesis of CoQ10, which further decreases levels in the body.

    Double blind controlled trials have shown that CoQ10 improves symptoms, functional capacity and quality of life in patients with heart failure with no side effects. But until now, no trials have been statistically powered to address effects on survival.

    The Q-SYMBIO study (2) randomised 420 patients with severe heart failure (New York Heart Association (NYHA) Class III or IV) to CoQ10 or placebo and followed them for 2 years. The primary endpoint was time to first major adverse cardiovascular event (MACE) which included unplanned hospitalisation due to worsening of heart failure, cardiovascular death, urgent cardiac transplantation and mechanical circulatory support. Participating centres were in Denmark, Sweden, Austria, Slovakia, Poland, Hungary, India, Malaysia and Australia.

    CoQ10 halved the risk of MACE, with 29 (14%) patients in the CoQ10 group reaching the primary endpoint compared to 55 (25%) patients in the placebo group (hazard ratio=2; p=0.003). CoQ10 also halved the risk of dying from all causes, which occurred in 18 (9%) patients in the CoQ10 group compared to 36 (17%) patients in the placebo group (hazard ratio=2.1; p=0.01).

    CoQ10 treated patients had significantly lower cardiovascular mortality (p=0,02) and lower occurrence of hospitalisations for heart failure (p=0.05). There were fewer adverse events in the CoQ10 group compared to the placebo group (p=0.073).

    Professor Mortensen said: "CoQ10 is the first medication to improve survival in chronic heart failure since ACE inhibitors and beta blockers more than a decade ago and should be added to standard heart failure therapy."

    He added: "Other heart failure medications block rather than enhance cellular processes and may have side effects. Supplementation with CoQ10, which is a natural and safe substance, corrects a deficiency in the body and blocks the vicious metabolic cycle in chronic heart failure called the energy starved heart."

    CoQ10 is present in food, including red meat, plants and fish, but levels are insufficient to impact on heart failure. CoQ10 is also sold over the counter as a food supplement but Professor Mortensen said: "Food supplements can influence the effect of other medications including anticoagulants and patients should seek advice from their doctor before taking them."

    Patients with ischaemic heart disease who use statins could also benefit from CoQ10 supplementation. Professor Mortensen said: "We have no controlled trials demonstrating that statin therapy plus CoQ10 improves mortality more than statins alone. But statins reduce CoQ10, and circulating CoQ10 prevents the oxidation of LDL effectively, so I think ischaemic patients should supplement statin therapy with CoQ10."

    References: 1. Heart Failure Congress 2013 http://www.escardio.org/congresses/hf2013/Pages/welcome.aspx?hit=nav 2. SA Mortensen, A Kumar, P Dolliner, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure. Results from the Q-SYMBIO study. Presented at Heart Failure Congress 2013 Final Programme Number 440. The full title of the Q-SYMBIO study is: "Coenzyme Q10 as adjunctive treatment of chronic heart failure: a randomised double blind multicentre trial with focus on changes in symptoms, biomarker status with BNP and long term outcome"?

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/d3uGwvq-8wM/130525143852.htm

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    Sunday, May 26, 2013

    Cambodian film on Pol Pot rule wins Cannes prize

    (AP) ? An autobiographical French-Cambodian film, "The Missing Picture," which explores the bloody history of Pol Pot's dictatorship in late 1970s Cambodia, has won the "Un Certain Regard" prize at the Cannes Film Festival.

    To rousing applause, director Rithy Panh collected the award at a ceremony Saturday night, expressing his gratitude to be able "to have the freedom to do the films I want to do."

    Panh's film, based on his nightmarish memoir "The Elimination," documents his own family's experience under the heavy-handed Communist Party's Khmer Rouge, which resulted in the death of his parents and sisters.

    The "Un Certain Regard" accolade, presented one day before the Palme d'Or and decided by a jury of cinema insiders, rewards works from up-and-coming filmmakers or those that transmit original messages and aesthetics.

    The premise of the "missing picture" in the film is that because of censorship within Cambodia, no photo exists that documents the atrocities committed against Panh's his family and relatives during Pol Pot's four-year reign of terror from 1975 to 1979.

    The tale is told using old documentary footage, or whatever footage remained from the time, which was mainly of propaganda by the dictatorship. To represent his deceased relatives, Panh used hundreds of carefully carved clay figures.

    Director Thomas Vinterberg, who was this year's jury president, said he was "very honored to be awarding this prize, which we all agree is for a fantastic movie."

    He praised all of the 18 works, which, as well as including several directorial debuts, were made up of a handful from well-known filmmakers such as Sofia Coppola, who opened the category with "The Bling Ring."

    "This selection was ferociously non-sentimental but poetic nonetheless. It was political, highly original, sometimes disturbing, varied, but above all unforgettable," Vinterberg said.

    "Clay figurines, extreme beauty, violence... systematic humiliation of human nature... are images that will follow us for a long time... Moments that remain in our collective memory, a mirror of our existence," he added.

    The "Jury Prize," the category's secondary award, was awarded to the Palestinian film "Omar," a war-torn love story, directed by Hany Abu-Assad.

    Vinterberg was one of a five-strong jury that included French actress Ludivine Sagnier and Chinese starlet Zhang Ziyi, who came to the stage wearing a sparkling white couture gown.

    ___

    Thomas Adamson can be followed at Twitter.com/ThomasAdamsonAP.

    Associated Press

    Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-05-25-France-Cannes-Un%20Certain%20Regard%20Prize/id-bebc68b1bc02400f873debde13a6ffe0

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    Saturday, May 25, 2013

    Rate of bicycle-related fatalities significantly lower in states with helmet laws

    Rate of bicycle-related fatalities significantly lower in states with helmet laws

    Friday, May 24, 2013

    Existing research shows that bicyclists who wear helmets have an 88 percent lower risk of brain injury, but researchers at Boston Children's Hospital found that simply having bicycle helmet laws in place showed a 20 percent decrease in deaths and injuries for children younger than 16 who were in bicycle-motor vehicle collisions.

    The cross-sectional study, conducted by William P. Meehan III, MD, Lois K. Lee, MD, MPH, Rebekah C. Mannix, MD, MPH of Boston Children's Hospital, and Christopher M. Fischer, MD, of Beth Israel Deaconess Medical Center, was published in the Journal of Pediatrics, and suggests that having these laws may influence parents to require their children wear helmets.

    "Past research shows that laws can be an important factor in helping parents adhere to best practice guidelines," says Meehan. "For parents who feel like there is conflicting information related to child health, this evidence supports the fact that helmets save lives and that helmet laws play a role."

    On average, 900 people die annually in bicycle-motor vehicle collisions?three quarters die from head injuries. At the start of the 12-year study (1999 to 2010), 16 states had bike helmet laws, and 35 did not. The researchers identified all relevant fatalities, totaling 1612, in states with and without bike helmet laws.

    After adjusting for factors previously associated with rates of motor vehicle fatalities (elderly driver licensure laws, legal blood alcohol limit and household income) the adjusted fatality rate was still significantly lower in states with helmet laws.

    To conduct the retrospective study, researchers analyzed data obtained from the Fatality Analysis Reporting System (FARS)?a census, compiled by the National Highway Traffic Safety Administration, which included information from all 50 states, including the District of Columbia and Puerto Rico.

    Since the FARS database is limited to injuries sustained during a motor vehicle collision that resulted in the death of at least one person within 30 days of the collision, the findings are likely an understatement of how important helmet laws are. "As a result of the data only capturing deaths, rather than all injuries, our findings likely underestimate the effects of the mandatory helmet laws, because we did not capture all pediatric bicycle-related injuries," says Mannix.

    The American Academy of Pediatrics recommends that all cyclists wear helmets that fit properly for each ride, and supports legislation that requires all cyclists to wear helmets.

    ###

    Boston Children's Hospital: http://www.childrenshospital.org/newsroom

    Thanks to Boston Children's Hospital for this article.

    This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

    This press release has been viewed 63 time(s).

    Source: http://www.labspaces.net/128394/Rate_of_bicycle_related_fatalities_significantly_lower_in_states_with_helmet_laws

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    Lawsuit alleging ex-QB Favre sent racy texts settled

    NEW YORK (AP) -- A lawsuit filed by two massage therapists who sued retired NFL quarterback Brett Favre over claims he sent racy text messages has been settled, a lawyer for the women said Friday.

    Lawyer David Jaroslawicz wouldn't comment on the terms of the settlement, saying only that the case had been ''resolved and discontinued.''

    Christina Scavo and Shannon O'Toole had alleged in a lawsuit seeking unspecified damages that in 2008, while Favre was playing for the New York Jets, they lost their part-time jobs with the team after complaining that he sent sexually suggestive texts to another therapist.

    During the 2008 preseason, the lawsuit alleged, the three-time NFL MVP sent another woman a text message asking to get together with her and Scavo, followed by another text saying, ''I guess I have bad intentions.''

    After Scavo's husband asked Favre to apologize, she and O'Toole lost gigs with the Jets, the lawsuit said.

    A lawyer for Favre didn't immediately respond to a call for comment Friday but has denied the allegations in the past, arguing in court papers that if the therapists lost work Favre wasn't responsible for it. A lawyer for the Jets also didn't immediately respond to a call seeking comment Friday.

    The therapists' lawsuit was filed five days after the NFL fined Favre $50,000 for not being forthright in an investigation into allegations that he sent bawdy text messages and photos to former Jets game hostess Jenn Sterger when they both worked for the team. During that investigation, media reports claimed Favre also had pursued massage therapists, but the NFL said it was unable to get enough information to decide whether the reports were substantiated.

    The Jets have said O'Toole and Scavo worked for the team for a combined total of five days over two years, making $2,300 in all, and were never guaranteed ongoing work. The team wasn't told about the women's concerns and simply turned to other massage therapists after its training facility moved in 2008, its officials and lawyers have said in court filings.

    Favre retired from the NFL in 2010, after playing for 20 seasons, mostly with the Green Bay Packers. He began his career with the Atlanta Falcons and ended it with the Minnesota Vikings.

    Source: http://news.yahoo.com/nyc-lawsuit-alleging-favre-sent-210933112--nfl.html

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    6 Top Shop Vacuums, Tested

    Ranking: ? ? ? ?
    Price: $90 to $110
    HP: 6
    Tank: 16 gallons
    15-pound pickup: 23 seconds
    Decibels, B scale: 85.3

    Likes: Reasonably powerful and quiet, the Craftsman is a good choice for both homeowners and contractors. We particularly liked its 20-foot power cord, the tenacious grip with which the hose locks to the tank, and the easy mounting and dismounting of the motor head.

    Dislikes: Needs better accessory storage?parts fall off too easily.

    Source: http://www.popularmechanics.com/home/reviews/power-tools/6-top-shop-vacuums-tested?src=rss

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    Moore shelter laws: Mayor seeks change after tornado devastation

    The mayor of the tornado-devastated town of Moore in Oklahoma has vowed to push for a new law on shelters, after a huge twister there killed at least 24.

    Glenn Lewis says he will propose an ordinance requiring a reinforced shelter to be built in every new home.

    Volunteers are now engaged in a recovery mission delivering supplies and helping people find accommodation.

    The White House says that President, Barack Obama, will travel to Moore on Sunday.

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    Source: http://go-jamaica.com/news/read_article.php?id=45098

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    Snooki: NJ Gov Christie 'just doesn't like us'

    New Jersey Gov. Christie speaks with Nicole "Snooki" Polizzi, center, and Jenni "JWoww" Farley, cast members of MTV's "Jersey Shore," on the boardwalk where he took part in a ribbon cutting ceremony to reopen the beach in Seaside Heights, N.J., on Friday, May 24, 2013. (AP Photo/Northjersey.com, Kevin R. Wexler)

    New Jersey Gov. Christie speaks with Nicole "Snooki" Polizzi, center, and Jenni "JWoww" Farley, cast members of MTV's "Jersey Shore," on the boardwalk where he took part in a ribbon cutting ceremony to reopen the beach in Seaside Heights, N.J., on Friday, May 24, 2013. (AP Photo/Northjersey.com, Kevin R. Wexler)

    (AP) ? New Jersey Gov. Chris Christie was never a fan of MTV's "Jersey Shore," saying it unfairly cast the state in a negative light.

    So when Nicole Polizzi, otherwise known as Snooki, got to meet the governor Friday and shake his hand, their exchange was a bit awkward.

    Christie and "Jersey Shore" cast members appeared separately on NBC's "Today" show during filming in Seaside Heights, N.J., to talk about the state's recovery from Superstorm Sandy. Seaside is where "Jersey Shore" was filmed.

    In a later exchange captured on video by the Asbury Park Press (http://on.app.com/ZiTFCx ), an unsmiling Snooki told Christie that she hoped he would "start to like us."

    Christie responded, "Well, we'll do our best."

    After they parted ways, Snooki looked at the camera and said, "He just doesn't like us."

    Associated Press

    Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-05-24-US-When-Christie-Met-Snooki/id-fa269ca1e484477089a402c9235d49bc

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    Friday, May 24, 2013

    'India must accept enviable friendship between China, Pak'

    Sorry, Readability was unable to parse this page for content.

    Source: http://feedproxy.google.com/~r/NewsXS_Pakistan/~3/4MhXvF-lKzE/

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    Scientists develop worm EEG to test the effects of drugs

    May 22, 2013 ? Scientists from the University of Southampton have developed a device which records the brain activity of worms to help test the effects of drugs.

    NeuroChip is a microfluidic electrophysiological device, which can trap the microscopic worm Caenorhadbitis elegans and record the activity of discrete neural circuits in its 'brain' -- a worm equivalent of the EEG.

    C. elegans have been enormously important in providing insight into fundamental signalling processes in the nervous system and this device opens the way for a new analysis. Prior to this development, electrophysiological recordings that resolve the activity of excitatory and inhibitory nerve cells in the nervous system of the worm required a high level of technical expertise -- single microscopic (1mm long) worms have to be trapped on the end of a glass tube, a microelectrode, in order to make the recording. The worms are very mobile as well as being small and this can be a challenging procedure.

    The microfluidic invention consists of a reservoir through which worms can be fed, one after the other, into a narrow fluid-filled channel. The channel tapers at one end and this captures the worm by the front end. The worm is then in the correct orientation for recording the activity of the nervous system in the anterior of its body. The device incorporates metal electrodes, which are connected to an amplifier to make the recording. The design of the trapping channel has been optimised by PhD student Chunxiao Hu, so that the quality of the worm 'EEG' recording is sufficient to resolve the activity of components of the neural circuit in the worm's nervous system.

    This device has been used to detect the effects of drugs and is highly suitable for high throughput screens (which allow researchers to quickly conduct millions of chemical, genetic or pharmacological tests) in neurotoxicology and for generic screening for neuroactive drugs. It has more power to resolve discrete effects on excitatory, inhibitory or modulatory transmission than previously possible with behavioural screens.

    Lindy Holden-Dye, Professor of Neuroscience at the University of Southampton and lead author of the paper, says: "We are particularly interested in using this as a sensitive new tool for screening compounds for neurotoxicity. It will allow us to precisely quantify sub-lethal effects on neural network activity. It can also provide an information rich platform by reporting the effects of compounds on a diverse array of neurotransmitter pathways, which are implicated in mammalian toxicology. "

    The research, which is published in the latest issue of the journal PLOS One, is a joint project between the University's Centre for Biological Sciences and the Hybrid Biodevices Group.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/suOlhI48VTI/130522180134.htm

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