Avuncular: Premier Stock Market ? Wall Street And Enron | Personal ...

May 30th | Wall Street And Enron

A major change in market practices is the result of the NASDAQ market-makers scandal and subsequent prosecution and fines. Equity markets began to move to decimal pricing rather than using fractions, as had been the custom since the eighteenth century. Pointing to the large differences used by NASDAQ, critics maintained that the abandonment of decimal fractions and the adoption would provide cleaner pricing and save the investing public a lot of money. Use of fractions was only adding needlessly pennies and fractions of cents to the price of a trade, which, naturally, went into the pockets of retailers. NASDAQ has entered the fray before the NYSE, using the 1997 scandal as an example of how to turn bad news into good future public relations. The NASD Chairman Frank Zarb, told a congressional committee in 2000 that the commitment of the NASD decimals was early and strong. As you know, the NASD was the first U.S. market to support prices WALL STREET 384 decimal, beginning with our testimony before the Subcommittee on April 16, 1997. The NASD Board on August 7, 1997 voted to begin operating systems using NASDAQ decimals.9 Not to be outdone by his rival, Richard Grasso announced that the NYSE would create a market ahead of the decimal NASDAQ for several months, in an obvious attempt to embarrass the NASDAQ, which had been billing itself as the stock market of the future in advertising. Both markets were trading decimal place in 2001. While the two stock markets engaged in healthy competition, the electronic communications networks, or ECN, has continued to develop, provide their own competition for the biggest markets. Dedicated to making markets in stocks selected using the setting to streamline procedures prescribed by the SEC, ECNs have continued to drain away the volume as NASDAQ and the NYSE, especially for large block trades in terms of well-traded issues. Private networks have been favored by large traders because the procedures have been streamlined and could get a performance of a stock veryquickly, better than the traditional order placing roads in place. And extending trading hours in the evening, the ECN has provided an additional service to institutional investors. For most, their services remain outside the sphere of the small investor unless he or she was a day trader, buying and selling quickly using Internet services online broker instead of a traditional telephone. Cross trades between the buyer and seller without the help of a market maker or specialist skills required of a trader, something the average investor does not have. After the bull market calmed down, the idea of ??trading afterhours lost part of its appeal, however, but ECNs remained favorites of some institutional investors. The decline of the small day trader after a severe decline in market volume of some injured, ECNs but they remained firmly in place among professionals.

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Tags: Avuncular:, market, premier, stock

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A few good men became basis of modern family

When women started to choose good providers over manly alpha males, they created the idea of the "couple," new research indicates.

The "modern family" is characterized by monogamy and long-term partnership, a phenomenon that replaced relative promiscuity with plenty of competition between males over mates.

When this change happened is up for debate, but ancient human Ardipithecus, at 4.4 million years old, already shows that competition between males had already declined. The development of the family seems to have happened soon after the hominins and chimpanzees split from each other evolutionarily.

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Over time, the study suggests, female mate choices changed; couples replaced promiscuity, while low-ranking men, who maybe weren't as strong or manly as alpha males, found a way around the male-on-male competition, by offering their services as long-term companions, rather than just sperm donors. This "sexual revolution," as the researchers called it, laid the foundation for the modern family.

Model families
In the new study, Sergey Gavrilets, a researcher at the University of Tennessee, analyzed mathematically how various theories about the development of the modern family would have played out. They show, with that analysis, that none of the previously proposed theories hold up biologically.

Using their modeling data, the researchers suggested that the only biologically feasible way for today's family to evolve would be if females started picking low-ranked males for their ability to take care of the female in a longer-term couplelike relationship (a capability called provisioning). [How Do I Love Thee? Experts Count 8 Ways]

These males spent their time and energy providing for their mates, instead of wasting this energy competing with other males. This gave these low-ranking males a way around traditional alpha-male competition, and if it helped the females raise more, or healthier, children, the trait would be selected for, and females would start to show a preference for these provider-males.

"Once females begin to show preference for being provisioned, the low-ranked males' investment in female provisioning over male-to-male competition pays off," Gavrilets said in a statement. "Once the process was under way, it led to a kind of self-domestication, resulting in a group-living species of provisioning males and faithful females."

Effect of family

When the modern family evolved, Gavrilets says, it gave rise to parenting partnerships and the division of labor, which is important because human children take so long to grow up. While these hominin males may be working their butts off for their ladies, the ladies may still stray, Gavrilets wrote in research detailed Monday in the journal Proceedings of the National Academy of Sciences.

"Females are not predicted to become completely faithful, but rather, the level of their faithfulness is expected to be controlled by a balance between selection for better genes (potentially supplied by top-ranked males) and better access for food and care (provided largely by low-ranked males)."

You can follow LiveScience staff writer Jennifer Welsh on Twitter, on Google+or on Facebook. Follow LiveScience for the latest in science news and discoveries on Twitterand on Facebook.

? 2012 LiveScience.com. All rights reserved.

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To spread, nervous system viruses sabotage cell, hijack transportation

ScienceDaily (May 30, 2012) ? Herpes and other viruses that attack the nervous system may thrive by disrupting cell function in order to hijack a neuron's internal transportation network and spread to other cells.

Princeton University researchers made the first observation in neurons that common strains of the herpes virus indirectly take control of a cell's mitochondria, the mobile organelles that regulate a cell's energy supply, communication with other cells, and self-destruction response to infection. The team reports in the journal Cell Host and Microbe that viral infection elevates neuron activity, as well as the cell's level of calcium -- a key chemical in cell communication -- and brings mitochondrial motion to a halt in the cell's axon, which connects to and allows communication with other neurons.

The authors propose that the viruses then commandeer the proteins that mitochondria typically use to move about the cell. The pathogens can then freely travel and reproduce within the infected neuron and more easily spread to uninfected cells. When the researchers made the mitochondria less sensitive to calcium the viruses could not spread as quickly or easily.

These findings reveal a previously unknown and highly efficient mechanism that some of the most common strains of herpes viruses in humans may use to proliferate in the nervous system, said lead author Tal Kramer, a doctoral student in the lab of the paper's co-author Lynn Enquist, the Henry L. Hillman Professor of Molecular Biology and chair of Princeton's molecular biology department.

Kramer and Enquist used rat neurons to study two herpes viruses in the alpha-herpes virus subfamily: pseudorabies virus (PRV), a model alpha-herpes virus that infects animals, and herpes simplex virus 1 (HSV-1), an extremely common human virus that causes cold sores and other lesions. Other human alpha-herpes viruses are responsible for causing diseases such as chicken pox and shingles.

"No one before has looked carefully at mitochondrial motion during alpha-herpes virus infection in neurons. We provide new insight into how these viruses damage cells in the nervous system in ways that are important for the virus to propagate," Kramer said.

"If mitochondria are stopped in their tracks and can't go anywhere, that is potentially very bad," he said. "They are not only the power plants of the cell, but regulate important processes. The virus likely acts to interfere with many of those processes."

Beyond herpes, the Princeton findings present a possible explanation for how other neurotropic viruses such as rabies, West Nile and polio attack and disrupt the nervous system, Kramer said. Although these viruses are different from the herpes family, the fact that HSV-1 and PRV had a similar effect on mitochondrial motion and function suggests that other pathogens could corrupt mitochondria in the same way, he said.

In addition, the paper lays out the implications of distorted mitochondrial function on neuron health. Mitochondrial malfunction is a known factor in non-infectious neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease, Kramer said, though the pathway to this disruption is not entirely known.

"Our model raises some new and exciting possibilities for future research on other important human viruses that can invade the nervous system and cause disease," Kramer said.

"And the fact that alpha-herpes infection damages the same key cellular function as neurodegenerative disorders also is striking," he said. "Understanding how viral infection damages neurons might give us insight into how diseases like Alzheimer's do the same. The viruses we study hijack well-studied cellular pathways that might make an effective target for future therapeutic strategies."

In a healthy neuron, mitochondria move throughout the cell's elongated, tree-like structure to provide energy for various processes that occur throughout the cell. For the strenuous task of long distance intercellular communication, mitochondria move along the axon and synapses, sites of cell-to-cell contact where signaling occurs.

Calcium plays a key role in this cell communication, Kramer explained. A neuron experiences a spike in calcium levels in the axon and synapses when it receives a signal from another neuron. Though a natural rover, mitochondria contain a protein called Miro that detects this rush of calcium and stops the organelles in the synapse. The mitochondria then provide energy as the cell passes a signal along to the next neuron.

Through live-cell imaging of neurons grown in the Enquist lab, Kramer and Enquist observed how this process becomes corrupted by HSV-1 and PRV -- and how the viruses need the process to spread.

The chaos begins when the virus ramps up the neuron's firing of electrical signals, as was first reported in a 2009 paper published in the journal PLoS Pathogens by Enquist; first author Kelly McCarthy, a past member of Enquist's lab who received her doctoral degree from Princeton in 2011; and David Tank, the Henry L. Hillman Professor of Molecular Biology and co-director of the Princeton Neuroscience Institute.

In the latest research, Kramer and Enquist found that this spike in electrical activity floods the axon and synapses with calcium. As a consequence, the Miro proteins detect the increase in calcium and stop mitochondrial motion. The virus' control over the cell immediately dropped off, however, when Kramer and Enquist interfered with Miro's ability to respond to the uptick in calcium levels. Though the viral infection was not completely disrupted, it could not spread within or to other cells with the same efficiency.

Based on these observations, Kramer and Enquist suggest that viruses such as HSV-1 and PRV may bring mitochondria to a standstill in order to hijack their transportation. Mitochondria move about the neuron on the backs of motor proteins dynein and kinesin-1. During viral infection, mitochondria shed these proteins to stop moving when Miro detects an upsurge in cellular calcium.

Previous research has shown that HSV-1 and PRV also use kinesin-1 specifically for transport within an infected cell. Thus, Kramer said, his and Enquist's work suggests that it is very likely that the viruses disrupt mitochondrial motility so that they can hitch themselves to the now available kinesin-1 proteins and move through the nervous system more efficiently.

James Alwine, a University of Pennsylvania professor of cancer biology, said that the Princeton research is a significant contribution to a growing body of research that describes how viruses seize cellular motor proteins such as kinesin-1.

While the findings have therapeutic potential -- particularly in helping show how balancing cellular calcium might subdue viral infection -- the demonstration that viruses can move through an infected cell with the ease of something as essential as mitochondria is notable in itself, said Alwine, who is familiar with the research but had no role in it.

"Determining the specific mechanism by which Miro function is abrogated may provide additional therapeutic avenues, but this also is marvelous basic research that does not have to be justified by its therapeutic potential," he said.

"To disrupt the loading of mitochondria to motor proteins so that virions [complete virus particles] can load instead is a clever way for a virus to be transported and is a great new idea provoked by this data," Alwine said. "While other neurotropic viruses would have to be tested specifically, movement in nerve cells is required by all of them. Thus, this observation provides a starting place and a model mechanism for research with those other pathogens."

This research was published May 17 in the journal Cell Host and Microbe, and supported by the National Institutes of Health and a National Science Foundation Graduate Research Grant.

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Story Source:

The above story is reprinted from materials provided by Princeton University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Tal Kramer, Lynn?W. Enquist. Alphaherpesvirus Infection Disrupts Mitochondrial Transport in Neurons. Cell Host & Microbe, 2012; 11 (5): 504 DOI: 10.1016/j.chom.2012.03.005

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Obama's health care aid to small firms disappoints

WASHINGTON (AP) ? It seemed like a good idea at the time.

But a health insurance tax credit for small businesses, part of President Barack Obama's health care law that gets strong support in public opinion polls, has turned out to be a disappointment.

Time-consuming to apply for and lacking enough financial reward to make it attractive, the credit was claimed by only 170,300 businesses out of a pool of as many as 4 million potentially eligible companies in 2010.

That's put the Obama administration in the awkward position of asking Congress to help fix the problems by allowing more businesses to qualify and making it simpler to apply.

But Republicans who run the House say they want to repeal what they call "Obamacare," not change it.

"They completely missed the target on this thing," Rep. Sam Graves, R-Mo., said of the tax credit. "I don't think expanding it is going to make any difference whatsoever." Graves chairs the House Small Business Committee.

It doesn't help the administration's plea that the biggest small-business lobbying group is a lead plaintiff asking the Supreme Court to overturn the Affordable Care Act. The National Federation of Independent Business isn't likely to spend much time tinkering with the tax credit or promoting it to members.

Small businesses represent the crumbling edge of the nation's system of employer-based health care. Only about 30 percent of companies with fewer than 10 workers offer health coverage, and they often pay more for insurance than large businesses. The credit, which once had support in principle from lawmakers of both parties, was supposed to help businesses already providing coverage afford the premiums. And maybe it would even entice some to start.

"We agree it is not a panacea for all costs," said John Arensmeyer, founder of Small Business Majority, an advocacy group that supports the health care law and disagrees with the much larger independent business federation. The problem is all the negative publicity around the health care law has discouraged business owners from applying for the credit, he says.

"There has been more heat than light shone on this," Arensmeyer said. "There is no reason why small businesses shouldn't be taking advantage of this credit." About 770,000 workers were covered by the businesses claiming the credit in 2010.

However, a recent report by Congress' nonpartisan Government Accountability Office identified several issues with the credit itself.

To begin with, the GAO said, the tax credit is structured so its biggest benefits go to very small companies paying low wages. About 4 out of 5 such businesses don't offer coverage, and the tax credit is not sufficient to encourage them to start doing so.

"Small employers do not likely view the credit as a big enough incentive to begin offering health insurance," the report said.

The average credit claimed in 2010 was about $2,700, although some companies qualified for much more.

Many small firms did not qualify because they paid fairly decent wages. The GAO report quoted an unidentified tax preparer who explained that "people get excited that they're eligible and then they do the calculations and it's like the bottom just falls out of it and it's not really there." It's almost a bait and switch.

Complexity has been another obstacle. IRS Form 8941, which employers must complete to claim the credit, has 25 lines and seven worksheets, the GAO said. Some tax preparers told the agency it took clients from two to eight hours to pull together supporting information and tax professionals another three to five hours to calculate the credit.

Trying to help, the IRS identified "three simple steps" employers needed to follow, but the GAO found "the three steps become 15 calculations, 11 of which are based on seven worksheets, some of which request multiple columns of information."

Arensmeyer said claiming the credit will be simpler once it becomes standard in tax-preparation software.

As it stands now, the credit is only temporary, expiring in 2016. That's another reason Congress appears unlikely to adopt the administration's proposed fixes, which would cost an estimated $14 billion that has to be offset with cuts elsewhere.

If the health care law withstands Supreme Court scrutiny, more employers could start claiming the credit. Otherwise, it may just go down as a missed opportunity, for policymakers and small-business owners alike.

___

Online:

The Government Accountability Office's report: http://tinyurl.com/7ae96hn

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Timeshare @ Teams Playa Real, Costa Del Sol ? Travel & Leisure ...

Thinking of buying, selling or renting Timeshares on the Costa Del Sol? Talk to the Travel & Leisure Group. Travel and Leisure Group are one of the largest and most respected Timeshare Resale Brokers of privately owned Timeshare properties in Europe, with

Timeshare @ Teams Playa Real, Costa Del Sol ? Travel & Leisure Collection

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Why Exercise and fitness Class Improves on Club/Membership Time ...

There?s a lot of free wellness and fitness programs that comes with individuals training raspberry ketone become health boosting and more content beings. And on top age would are generally a authentic excuse in order to avoid them.

The ideal thing to do about the web is of which information can be purchased when together with where you choose it ? it happens to be interactive and also dynamic. This may be tracked as a result of knowing all the progress on the maximum pulse rate percentage or the condition of exertion which is perceived. Another significant of whatever fitness exercise and diet program is freedom which educates on the pain because of the structures motion. Most persons cannot afford to make a trainer to offer you them tips and support every time they need the application.

diet pills achieve your fit heart is through cardio exercises. ) Produce a Visualization Table that features images from your Biggest Goals and objectives. Hang it again somewhere in order to see it again often (Maybe during the TV computer screen! ).

Having a fitness internet business and posting fitness coach May possibly spent much time in a health club. I see every type, it?s to some extent, what creates my task so nice. You may as well use TV SET and DVD to build them curious about sports and also other exercise by permitting them to watch the best way fun it?s always to undertake it.

Germs can raspberry ketone items that had been left unattended for a time. Observed responsible blogger Joanne Thomas, "Avoid foods and help to make meals and also snacks in your own home." The health and fitness health test is an effective way those of you that are interested in their exercise and wellness to assess their correct wellness right now. Yet, prevention is critical in assisting you to avoid decreased back problems and harm.

Yoga may be the Hindu control or method of workouts that enhance control along with relaxation of this mind and body. A number of people procedure yoga just for various explanations. Some decide to do that to sense at peace as well as some do it to misplace weight. Hopefully you can start weight lifting soon and you will definitely find for you to definitely shed weight and use up more excess fat.

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The Advantages of Having a Real estate agent

All you need to do is appear around your town or city to see WHY you need to have a real estate agent. Attributes are becoming bought and marketed daily with the benefit of market place research and arranging. Frequently times these two components are outdoors the scope of someone who wishes to promote their own household. Sure, you realize what sort of equity you put into your own dwelling, but just how much did that other residence down the road offer for? What sort of pricing is impacting the homes around you currently? Do you know how you can attain out to potential household purchasers? These questions all lend to factors why you will find advantages of getting a real estate agent.

Advantage 1: Industry Analysis

Realtors possess the benefit of not just looking the MLS (Several Listing Services) for you personally whilst finding a household or house you may like, but they also are aware about any phone phone calls that occur in to the workplace that may be from new retailers who are wishing to sell as quickly as possible with no planning into the MLS. As a person who is not represented by a genuine estate agent, you?d be missing out on these deals. Brokers also have the benefit of researching market analyses of unique residence types inside the area that you simply are planning to obtain or promote in. This really is priceless information and facts because it would go towards just how much some thing is absolutely really worth.

Benefit 2: Arranging and Consultation

Realtors will be the individuals who have gone by means of helping with 100?s of house closings and home marketing situations. They?re those to consult with in understanding the way to sell your home. Do you maintain you animals absent whenever you possess a home exhibiting, and how much would you thoroughly clean up? What do you want to highlight and what do you would like to keep within the history. These are all concerns that actual estate brokers can help with.

Advantage 3: They?re on your side

You?ll in no way have a person as ferocious in your side to help you buy or sell a home. Realtors are commission based mostly for his or her service fees, however they depend on their network of clients to bring within their next consumer. With no their community, they wouldn?t have any one to signify. That being mentioned, they?ll do every little thing possible to get what you wish. Without the need of fulfilling their customers, they?d don?t have any clientele!

As you are able to see, realtors give quantified benefits outside of assisting in purchasing or marketing your home. They comprehend the nuances, the paperwork, and many importantly- your wants. For far more facts of resources and listings to go looking.

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Visiting Resorts In Jamaica | Travel and Leisure Blog

Jamaica is one of the most popular vacation destinations in the world. There is good reason for that. This tropical island is home to pristine beaches, incredibly clean water, mouthwatering cuisine, a world of amenities and friendly people. What more could you ask for when traveling? The most difficult aspect of traveling to Jamaica is choosing the right place to stay. That being the case, we will look at the best resorts in Jamaica and lead you in the right direction.

When it comes to the best resorts in Jamaica, you have to go with a Sandals property. There are seven of them to choose from. They each offer something different so pay careful attention, heed the advice given and you will be well on your way to the best vacation of your entire life.

Beaches is one of the top resorts in Jamaica. This has everything to do with amenities. Here you will find pools, beaches, tennis courts, an outdoor restaurant, indoor fine dining, a romantic pier with a bench to enjoy sunset views, boating activities and more. Another good option is Wyndham. However, this is a very basic hotel. The outdoor fountains, balconies, outdoor pool and outdoor bar are the biggest selling points. Just don?t expect to be blown away. Iberstor Rose Hall is quality. The beach, pool, staff and food are all impressive. At the same time, there is nothing overly memorable about this location.

Moving to the north side of the island, we have Sandals Royal Plantation. This property is near the St. Ann Mountains and the Ocho Rios Rivera. This is the perfect place to stay if you don?t like crowds and you enjoy nature and exploring. There are 77 suites here. Every single one of them comes with an ocean view.

If you?re looking for romance, then go straight to Sandals Negril. This property is located on the famous seven-mile beach, which means a lot of space when you?re looking to suntan as well as beauty as far as the eye can see when you?re looking out over the water. This is an environmentally friendly resort with unique architecture.

Sandals Grand Rivera is the prettiest of all the Sandals resorts. That?s because it?s set on a 110-acre preserve that?s part of a rainforest. Therefore, you have mountain views to one side and the beach to the other. There are also gardens, streams and 100 pools to enjoy.

Sandals Montego Bay has been around forever and people still flock to it. That?s because it has the largest beach and the cleanest water on the island. There are also roofed huts on the beach for guests to enjoy.

Finally, we have the Sandals Carlyle, which is best suited for couples. This is one of the smaller resorts in Jamaica. While it has all the basic amenities, two great features are that it?s home to two gourmet restaurants and it?s only five minutes from the airport.

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RENEWABLE ENERGY: Grid problems steer China's huge wind power industry into financial doldrums